Tennis icon Serena Williams has spoken candidly about her use of GLP-1 medication to improve her health and fitness after pregnancy. Her openness has drawn attention to the growing conversation around medical support for weight management.
Williams admitted that despite years of professional training, intense workouts, and hours of walking and running, she struggled to return to her desired health level. After the birth of her second child, the challenge became even greater, prompting her to try GLP-1 therapy. She credits the medication with helping her lose around 31 pounds while also boosting her energy, easing pressure on her joints, stabilizing blood sugar, and improving focus. Still, she emphasized it was not a “shortcut” but an added tool alongside her exercise and diet routine.
Understanding GLP-1 Drugs
GLP-1 (Glucagon-Like Peptide-1) medications mimic natural hormones that regulate appetite and blood sugar. They slow digestion, reduce cravings, and help users feel full faster. Commonly prescribed for diabetes, these drugs also support weight loss. Popular versions include Ozempic, Wegovy, Mounjaro, and Zepbound — the latter being the one Williams has used.
Doctors note that medications like semaglutide can reduce body weight by around 12%, while tirzepatide (used in Zepbound) can lead to even greater results, averaging 18% or more.
Not a Magic Pill
Despite their effectiveness, health experts warn that GLP-1 drugs must be combined with a balanced diet, physical activity, and good sleep. “It’s not about shortcuts,” Williams stressed, echoing medical advice that lifestyle remains the foundation of long-term health.
Dr. Richa Chaturvedi, an endocrinologist at Apollo Hospital, explained that results vary by individual and that informed use under medical supervision is crucial. She also pointed out risks, including nausea, constipation, and in rare cases, pancreatitis or thyroid-related complications.
Balancing Benefits and Risks
Doctors caution that patients with thyroid cancer history should avoid these drugs, and anyone using them should support treatment with strength training and adequate protein to limit muscle loss. Research suggests muscle reduction during treatment can range from 15–40%.
Experts agree that while these medications can be a game-changer for those who struggle despite lifestyle efforts, they should complement — not replace — healthy living habits. As Dr. Manoj Agarwal of Shalby Hospital put it, “Lifestyle is still the backbone, but for some people, GLP-1 can be transformative.”
